approval of tamoxifen for women with a high risk of breast cancer

what medicine can prevent breast cancer?

with the increase of age, female breast cancer will be more and more big, like heart disease or osteoporosis as. Eat statins or aspirin can prevent cardiovascular disease, calcium to prevent osteoporosis, a similar drug can prevent breast cancer? Some drugs, such as aromatase inhibitors and selective estrogen receptor modulators can indeed play a preventive effect of breast cancer.

aromatase inhibitors can reduce the release of oestrogen to prevent breast cancer. Estrogen is not only to promote the development of women’s sexuality, will also promote some breast tumor growth, and our bodies rely on aromatase to the production of estrogen, inhibited aromatase as a fundamental solution to the tumor. Exemestane is the new aromatase inhibitors. USA over a 3 year trial showed, compared with placebo for women, taking the chance of exemestane of female breast cancer was reduced by 65%. At present, more research is confirmed according to the preventive effect of exemestane whether can continue, will bring side effects.

selective estrogen receptor modulators, are the most discussed the prevention of breast cancer drug tamoxifen is. It can reduce the risk of breast cancer in women by reducing the effects of estrogen on the body. American a program called "study of breast cancer prevention trial" discovery, taking 5 years of tamoxifen (60 mg daily), can reduce the risk of developing breast cancer in postmenopausal women 50%. American food and Drug Administration (FDA) approval of tamoxifen for women with a high risk of breast cancer, to reduce the risk of breast cancer. Also called a selective estrogen receptor modulator raloxifene, was approved by the FDA for the prevention of breast cancer. In the clinical trials, taking raloxifene 25 mg per day, for 5 years, can reduce the risk of female breast cancer 35%.

how to determine who will benefit?

even tamoxifen and raloxifene has been approved by the FDA for the prevention of breast cancer, but the side effects of the drug are still worrying. Selective estrogen receptor modulators in certain parts of the body can play to reduce the effects of estrogen, can in some other parts of the body will have the opposite effect. For example, tamoxifen is a selective estrogen receptor modulators in breast tissue in the uterus and bones, but as estrogen receptor agonists, which may increase the risk of uterine cancer and endometrial cancer (although very low). However, for patients with breast cancer high risk women, drugs may harm is far lower than the benefits of preventive effect.

so, what women could benefit from preventive drugs outweigh the risks? How to pick out those high risk women is a problem. Cholesterol levels and blood pressure level can accurately predict the risk of heart disease, and cholesterol lowering drugs can effectively prevent heart disease. In the prevention of breast cancer, but no such markers of cholesterol. BRCA1 and BRCA2 gene mutation is indeed able to predict the risk of breast cancer, but >

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